SUNBRIGHT GS-050 (DSG-PEG5000) is a PEGylated lipid designed to enhance stability and efficiency of lipid nanoparticle (LNP) drug delivery systems. It features two C18:0 fatty acids (18 carbon atoms, no double bonds, stearic acid) connected at the 1- and 2-positions of a glycerol backbone, and a polyethylene glycol (PEG) chain of 5,000 Da linked at the 3-position. By incorporating polyethylene glycol (PEG) into the surface of LNPs, it improves the stability and circulation time of LNPs in the bloodstream, facilitating efficient delivery of encapsulated therapeutic agents such as mRNA, siRNA, and other nucleic acids.
Acronym: DSG-PEG 5,000
Chemical Name: 1,2-Distearoyl-rac-glycero-3-methylpolyoxyethylene
CAS#: 308805-39-2
PEG chain Molecular weight: 5000
Alkyl composition: R1COO= C18:0, R2COO= C18:0
