NOF Attends World ADC Berlin 2018




  CHINPI EXTRACT K65B                                 
 Citrus tachibana peel extract for skin whitening.                                                                       

 Citrus tachibana peel extract can be utilized as an agent for the treatment of skin pigmentation such as spots and freckles induced by UV. Tachibana is the traditional orange plant in Japan. The peel is known as Chinese herb medicine ‘Kippi’. It is prescribed for stomachic digester, antitussive agent and expectorant drug in Chinese herbal remedy, and also mixed in folk medicine for aromatic stomachic. 


  Product Features                                                                                                                

 Inhibition of Melanin Formation
CHINPI EXTRACT K65B inhibits melanogenesis in HM3KO cultured human melanoma cells. The inhibitory mechanism involve suppression of the biosynthesis of tyrosinase.

 Identification of whitening agents from Chinpi Extract
We attempted to purify effective skin-whitening agents from Citrus tachibana peel extract, and it was found that nobiletin and tangeretin, which belong to polymethoxyflavone, were identified as skin-whitening agents.

  Photoprotective effect
CHINPI EXTRACT K65B provide protection against UVB induced cell damage.


  2   Composition / Information / Specification                                                                                  


INCI Name CAS No. Content
BUTYLENE GLYCOL 107-88-0 64.0%
WATER 7732-18-5 34.4%


Test Item Specification
Appearance Light yellow to yellow-brown liquid
Ordor Faint characteristic odor
Identification (Flavonoids) Positive
Purity (1) Heavy metals Max. 20 ppm
Purity (2) Arsenic Max. 2 ppm
Residue on Evaporation 0.8 – 2.5 w/v%


 Safety Data

1. Acute oral toxicity 2. Primary skin irritation
3. Ocular irritation 4. Skin sensitization
5. Phototoxicity 6. Photosensitization
7. Cumulative application 8. Reverse mutation (Ames)
9. Human patch 10. Comedogenicity assay

 Packaging: 1kg, 10kg



 3  Experimental Data                                                                                                       

 1. Inhibitory effect on melanogenesis                                2. Photoprotective effect