2-2. Activated PEG diacylglycerols

For site specific delivery, nanoparticles modified with ligands are widely used. Conventional modifying agents,
like activated PEG-phospholipids, have a ionic-charge. It is not appreciate to apply them to lipid nanoparticles (LNP),
because they have a negative impact on a charge and stability of LNP. Our “Activated PEG Diacylglycerol” has no
charge, so it is useful for preparing site specific LNP.

Reference articles of targeting LNP :
1. T. Ishida et al., FEBS Letters, 1999, 460, 129-133.
2. C. Chen et al., International Journal of Nanomedicine, 2011, 6, 2567-2580.