SUNBRIGHT ME-3E050FH-EA*

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SUNBRIGHT ME-3E050FH-EA is a pH-triggered releasable PEG derivative incorporating an acid-cleavable acetal linker, designed to release conjugated pharmaceutical substances under mildly acidic conditions (pH 4–6), such as in endosomes, lysosomes, or tumor tissues. It consists of a 5,000 Da PEG chain connected to an acid-cleavable linker that has a primary amine group.

The acetal linker remains stable at physiological pH (7.4) while selectively cleaving under acidic environments to trigger drug release. The release rate can be fine-tuned by modifying the substituents on the benzene ring.

ME-3E050FH-EA offers excellent serum stability and storage stability, making it particularly suitable for targeted drug delivery systems requiring precise control of release timing in specific biological environments.

Amine

-NH2 , Mw 5,000

Package size: 100mg or 1g

*: make-to-order

Applications For Protein and Peptide Conjugate
Functional Groups Aminoethyl
MW 5,000
Package Size 100mg, 1g
PEG Type Releasable PEGs
Target Groups Carboxylic acid
Package Size
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