SUNBRIGHT GS-034EX(DSG-PEG)*
SUNBRIGHT GS-034EX is a PEGylated lipid (commonly known as DSG-PEG3400) designed to enhance stability and efficiency of lipid nanoparticle (LNP) drug delivery systems. It features two C18:0 fatty acids (18 carbon atoms, no double bonds, stearic acid) connected at the 1- and 2-positions of a glycerol backbone, and a polyethylene glycol (PEG) chain of 3,400 Da linked at the 3-position. By incorporating polyethylene glycol (PEG) into the surface of LNPs, it improves the stability and circulation time of LNPs in the bloodstream, facilitating efficient delivery of encapsulated therapeutic agents such as mRNA, siRNA, and other nucleic acids.
Key Features:
- Enhanced Stability: The PEG moiety of GS-034EX forms a hydrophilic layer around LNPs, reducing aggregation and increasing stability in biological environments.
- Prolonged Circulation: Extends the half-life of LNPs in the bloodstream, improving bioavailability of the encapsulated therapeutic agents and therapeutic outcomes.
- Efficient Delivery: Optimized for the encapsulation and transport of nucleic acids, GS-034EX ensures effective delivery to target cells, enhancing therapeutic efficacy.
- Broad Applicability: Suitable for use in vaccines, gene therapies, and other nucleic acid-based therapeutics.
GS-034EX is a trusted component of LNPs to improve the delivery and performance of LNPs in advanced drug delivery systems.
Acronym: DSG-PEG 3,400
Chemical Name: 1,2-Distearoyl-rac-glycero-3-methylpolyoxyethylene
CAS#: 308805-39-2
PEG chain Molecular weight: 3400
Alkyl composition: R1COO= C18:0, R2COO= C18:0
Package: 1g amber glass bottle or 10g aluminum pouch.
*: make-to-order
